Buffalo Bills and Los Angeles Rams have played a total of 14 games against each other, including the regular season and playoffs. The Bills have won 9 of these games, while the Rams have won 5 times. No games between the Bills and Rams ended in ties. The Bills and Rams have never faced each other in a playoff game.
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Buffalo Bills vs Los Angeles Rams Head To Head Records & Stats
| Event | Games | Buffalo Bills Won | Los Angeles Rams Won | Ties |
| NFL Regular Season | 14 | 9 | 5 | 0 |
| NFL Playoffs | 0 | 0 | 0 | 0 |
| Overall | 14 | 9 | 5 | 0 |
Buffalo Bills vs Los Angeles Rams H2H Longest Winning Streaks
The longest winning streak for the Buffalo Bills over the Los Angeles Rams is 3 games. The streak started on 9 October 2016 and ended on 8 September 2022. On the other hand, the longest winning streak for the Los Angeles Rams over the Buffalo Bills is 2 games. The streak started on 27 September 1970 and ended on 15 December 1974.
Buffalo Bills vs Los Angeles Rams: Last 10 Games Results
| Date | Home Team | Visiting Team | Winning Team | Final Score |
| 09/08/2022 | Los Angeles Rams | Buffalo Bills | Buffalo Bills | 10-31 |
| 09/27/2020 | Buffalo Bills | Los Angeles Rams | Buffalo Bills | 35-32 |
| 10/09/2016 | Los Angeles Rams | Buffalo Bills | Buffalo Bills | 19-30 |
| 12/09/2012 | Buffalo Bills | Los Angeles Rams | Los Angeles Rams | 12-15 |
| 09/28/2008 | Los Angeles Rams | Buffalo Bills | Buffalo Bills | 14-31 |
| 11/21/2004 | Buffalo Bills | Los Angeles Rams | Buffalo Bills | 37-17 |
| 09/20/1998 | Buffalo Bills | Los Angeles Rams | Los Angeles Rams | 33-34 |
| 12/10/1995 | Los Angeles Rams | Buffalo Bills | Buffalo Bills | 27-45 |
| 09/06/1992 | Buffalo Bills | Los Angeles Rams | Buffalo Bills | 40-7 |
| 10/16/1989 | Buffalo Bills | Los Angeles Rams | Buffalo Bills | 23-20 |
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