Buffalo Bills and Arizona Cardinals have played a total of 12 games against each other, including the regular season and playoffs. The Bills have won 7 of these games, while the Cardinals have won 5 times. No games between the Bills and Cardinals ended in ties. The Bills and Cardinals have never faced each other in a playoff game.
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Buffalo Bills vs Arizona Cardinals Head To Head Records & Stats
| Event | Games | Buffalo Bills Won | Arizona Cardinals Won | Ties |
| NFL Regular Season | 12 | 7 | 5 | 0 |
| NFL Playoffs | 0 | 0 | 0 | 0 |
| Overall | 12 | 7 | 5 | 0 |
Buffalo Bills vs Arizona Cardinals H2H Longest Winning Streaks
The longest winning streak for the Buffalo Bills over the Arizona Cardinals is 4 games. The streak started on 21 September 1986 and ended on 31 October 2004. On the other hand, the longest winning streak for the Arizona Cardinals over the Buffalo Bills is 2 games. The streak started on 15 November 1981 and ended on 9 September 1984.
Buffalo Bills vs Arizona Cardinals: Last 10 Games Results
| Date | Home Team | Visiting Team | Winning Team | Final Score |
| 11/15/2020 | Arizona Cardinals | Buffalo Bills | Arizona Cardinals | 32-30 |
| 09/25/2016 | Buffalo Bills | Arizona Cardinals | Buffalo Bills | 33-18 |
| 10/14/2012 | Arizona Cardinals | Buffalo Bills | Buffalo Bills | 16-19 |
| 10/05/2008 | Arizona Cardinals | Buffalo Bills | Arizona Cardinals | 41-17 |
| 10/31/2004 | Buffalo Bills | Arizona Cardinals | Buffalo Bills | 38-14 |
| 12/19/1999 | Arizona Cardinals | Buffalo Bills | Buffalo Bills | 21-31 |
| 11/11/1990 | Buffalo Bills | Arizona Cardinals | Buffalo Bills | 45-14 |
| 09/21/1986 | Buffalo Bills | Arizona Cardinals | Buffalo Bills | 17-10 |
| 09/09/1984 | Arizona Cardinals | Buffalo Bills | Arizona Cardinals | 37-7 |
| 11/15/1981 | Arizona Cardinals | Buffalo Bills | Arizona Cardinals | 24-0 |
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